Yes, there are those that cannot be fully utilized for reasons of how they are implemented and others, like defining subroutines, where there is not enough benefit in being able to do them in direct mode to make it worthwhile to offer them.I know how that works, I just wanted to point out the other direction, there are some constructs which cannot be (fully) utilized in direct mode.
The whole point of direct mode is that it is a program that is written, executed, and then overwritten by the next direct mode program.
If you define a subroutine in direct mode, the next direct mode entry you write can't use the subroutine, because it's over-written the subroutine. Given 16K or 32K or 64K, there's no particular reason to try to create a direct mode subroutine definition ability when you can interactively define the subroutine as the current program and THEN call it in direct mode.
But "Basic is interactive and therefore omits some of the structured blocks" is a specious argument, since the interactivity of Basic is not limited to direct mode.WHILE...WEND on the other hand could be used in direct mode like a FOR...NEXT loop. So the argument of BASIC being interactive and therefore omitting some of the structured blocks don't fit.
And the DO/LEAVE/LOOP construct can also be used as a conditional loop in direct mode, as can full fledged QBasic DO/LOOPs.
But as noted, the most direct ELSE implementation in BASIC results in a non-nesting IF-THEN-ELSE construct. So without additional block capabilities or alternative Block versions of THEN and ELSE, some of those GOTOs would still be there. But at the very least a single-line, non-nesting ELSE is needed to let the DO/LEAVE/LOOP work as a conditional loop in direct mode.The worst omission cause of space constraints is the lack of ELSE which leads to a lot of unnecessary complicated constructs with IF...THEN and GOTOS so simulate the ELSE case.